RNF220 (Ring Finger Protein 220): RNF220 is a protein that belongs to the ring finger family, known for its ring finger domain involved in protein interactions and ubiquitination. It functions as an E3 ubiquitin ligase, playing a key role in the ubiquitin-proteasome system responsible for protein degradation and cellular balance. RNF220 helps regulate important cellular activities like signal transduction, gene expression, and the cell cycle. Disruptions in RNF220 function have been linked to diseases such as cancer and neurodegenerative disorders.