DSP (Desmoplakin) is a key protein that acts as a structural linker within cells, essential for the integrity and function of desmosomes—specialized cell-cell adhesion complexes found in epithelial and cardiac tissues. DSP plays a vital role in maintaining mechanical strength and cellular cohesion by anchoring intermediate filaments to desmosomal cadherins. This connection supports tissue stability in areas exposed to high mechanical stress, such as the skin, heart, and certain mucous membranes. Mutations in the DSP gene are linked to various genetic disorders, including cardiomyopathies and skin diseases, underscoring its importance in tissue architecture and function.